Dr. Ruoxuan Sun | Immunogenicity of Biotherapeutics | Best Researcher Award

Takeda Pharmaceutical, United States

👨‍🎓Profiles

• Scopus Profile
• ORICD Profile
• Google Scholar

🎓 Early Academic Pursuits

He began their academic journey at Peking University, earning a Bachelor of Science (B.S.) in Pharmaceutical Sciences. Building upon this foundation, they pursued a Master of Science (M.S.) in the same discipline, demonstrating exceptional research capabilities. Continuing their academic excellence, Sun completed a Ph.D. in Pharmacy at Purdue University, where they delved into groundbreaking studies on immunotherapy and molecular biology.

💼 Professional Endeavors

Currently serving as a Research Senior Scientist at Takeda Pharmaceuticals in Cambridge, MA, He has been with the compan, ascending from Research Scientist I to their present senior role. Their responsibilities include: Anti-drug antibody (ADA) assay development for pre-clinical studies, Innovative wash-free platforms for bioanalysis using NanoBiT and fluorescence polarization strategies, Epitope profiling and immunogenicity risk assessment for novel therapeutic modalities, In silico and in vitro immunogenicity evaluations to assess and mitigate immunogenicity risks in large molecules and biotherapeutics.

🧪 Contributions and Research Focus

His research at Takeda and Purdue University spans a wide array of scientific domains: ADA assay innovations for therapeutic candidates such as antibodies, oligonucleotides, and lipid nanoparticles, Epitope mapping strategies to assess immunogenicity and optimize therapeutic candidates, Post-translational modification regulation of immune receptors, including the identification of FBXL20 as a regulator of 4-1BB, Cancer immunotherapy development, focusing on glycosylation targeting and immunotherapy combinations.

🌍 Impact and Influence

He has significantly influenced the fields of immunogenicity, bioanalysis, and cancer therapy through innovative research and industrial contributions. Their work has informed drug development processes, improved assay platforms, and expanded understanding of immunogenicity risks in preclinical and clinical studies. As a journal reviewer for esteemed publications like Redox Biology and Biomarker Research, Sun has contributed to the dissemination of high-quality research in their field.

📈 Academic Cites and Achievements

During their academic career, Sun authored pivotal publications focusing on the regulation of 4-1BB and cancer immunotherapy. Their impactful work has been recognized within the scientific community, leading to high citation metrics and collaborations with leading researchers.

🛠️ Technical Skills

He possesses a versatile skill set, blending expertise in immunogenicity assessment, molecular and cellular biology, biochemistry, and computational biology. Key proficiencies include: Development and validation of ADA and biomarker assays, Advanced protein purification and molecular cloning techniques, In silico modeling using platforms like Alphafold to predict immunogenicity.

📚 Teaching Experience

As a Graduate Teaching Assistant at Purdue University, He contributed to multiple academic disciplines: Organic Chemistry II Lab, Human Anatomy and Physiology Lab, Immunology, Integrated Pharmacotherapy. Their teaching fostered a new generation of pharmaceutical scientists, emphasizing practical skills and theoretical understanding.

🌟 Legacy and Future Contributions

His pioneering work in immunogenicity risk assessment and bioanalysis platform development has paved the way for safer and more effective therapeutic modalities. Looking ahead, Sun aims to further advance innovations in biotherapeutics, leveraging cutting-edge techniques and computational tools to address emerging challenges in drug development.

📖Notable Publications