Dr. Kaiyin Yang | Molecular Biology | Research Excellence Award
North China University of Science and Technology | China
Dr. Kaiyin Yang is a pharmacologist with a Doctor of Medicine degree, specializing in protein structure-based drug discovery and small-molecule targeted protein degradation. His research focuses on the rational design, synthesis, and mechanistic evaluation of novel anticancer agents, particularly PROTACs and enzyme-targeting small molecules. As Principal Investigator of a Hebei Provincial Youth Science Fund project, he is developing innovative HK2-targeting degraders for colon cancer therapy. His work also includes kinase inhibitors, metabolic enzyme modulation, and natural product-derived anticancer compounds. Dr. Yang’s studies integrate medicinal chemistry, chemical biology, and pharmacological approaches to advance precision oncology and targeted cancer therapeutics.
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Featured Publications
Design, synthesis, and biological evaluation of hydrophobic-tagged poly (ADP-ribose) polymerase 1 (PARP1) degraders
– Bioorganic Chemistry, 2026
A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2
– Chinese Chemical Letters, 2024
Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminase
– Bioorganic Chemistry, 2019