Utkal Sapkota | Chemical Safety | Young Scientist Award

Mr. Utkal Sapkota | Chemical Safety | Young Scientist Award

Institute of Agriculture and Animal Science, Nepal

Academic Profiles

Early Academic Pursuits

Mr. Utkal Sapkota began his academic journey in agricultural sciences at the esteemed Tribhuvan University, where he pursued a Bachelor of Science in Agriculture at the Paklihawa Campus. His undergraduate thesis centered on the in-vitro evaluation of plant extracts against Rhizoctonia solani, the causal organism of rice sheath blight. This project laid a solid foundation in phytopathology and botanical pesticide research. During his bachelor studies, he also explored biorational pest control methods, including the design of experiments using two-factorial Randomized Complete Block Design and statistical analysis via R Studio. His work with botanicals such as Azadirachta indica, Allium sativum, Lantana camara, and others highlighted an early inclination toward sustainable pest management approaches.

Professional Endeavors

Following his foundational studies, Mr. Sapkota advanced to postgraduate research at the Institute of Agriculture and Animal Science, Post Graduate Campus, Kathmandu. He earned his Master of Science in Agriculture, specializing in Entomology. His thesis, “Lethal and Sublethal Effects of Beauveria bassiana Commercial Products on Spodoptera frugiperda,” involved intensive bioassays under laboratory conditions. As a graduate research assistant under the guidance of a senior scientist from the Nepal Agricultural Research Council, he conducted extensive research on insect-pathogen interactions, particularly focusing on Beauveria bassiana and Metarhizium anisopliae, which are significant in biocontrol.

Contributions and Research Focus

His research interests span emerging contaminants, pesticide fate, computational toxicology, and environmental risk assessment. These interests reflect a deepening commitment to the intersection of environmental health and agricultural productivity. At the Nepal Agricultural Research Council, he contributed to several high-impact experiments such as mass rearing of the fall armyworm (Spodoptera frugiperda) and brown plant hopper (Nilaparvata lugens), quantification of conidia using a hemocytometer, and efficacy testing of fungal and chemical insecticides through bioassays.

Furthering his scope, Mr. Sapkota worked as a researcher at Progressive Sustainable Developers Nepal, where he implemented behavioral modeling frameworks such as the Theory of Planned Behavior and the Protection Motivation Theory to assess farmer pesticide-use behaviors. This role included gathering both qualitative and quantitative data via household surveys, focus group discussions, and key informant interviews, aiming to develop sustainable pesticide safety protocols based on farmer psychology and local practices.

Impact and Influence

His research contributes to real-world agricultural sustainability, offering innovative insights into biopesticide application, entomopathogenic fungi efficacy, and farmer behavioral change modeling. Through his field and lab-based investigations, Mr. Sapkota has supported initiatives aimed at reducing chemical pesticide dependency, which is critical in contexts where environmental degradation and health risks are closely linked to agricultural inputs. His work also supports policy-level interventions on safe pesticide usage and pest risk management.

Academic Contributions and Collaborations

Throughout his academic trajectory, Mr. Sapkota has been involved in both independent and collaborative projects. As a research intern at the Molecular Biology Laboratory of the National Biotechnology Research Center, he honed molecular biology techniques including DNA extraction using the CTAB method, RT-qPCR, and gel electrophoresis. This molecular skillset reinforces his potential for integrated approaches combining traditional entomology with biotechnology and toxicology. He has also contributed to institution-funded and internationally-backed research, including projects supported by the Asian Food and Agriculture Cooperation Initiative. His interdisciplinary collaborations have bridged entomology, plant pathology, molecular biology, and data science.

Technical Skills

He possesses a broad and valuable technical skillset. His laboratory competencies include entomopathogenic fungi isolation and culture, microscopy, conidial quantification, bioassays, and fungal morphological studies. He is proficient in advanced analytical tools such as LC-MS/MS and GC-MS/MS, crucial for identifying pesticide residues and environmental contaminants. His software proficiency spans R Studio, SPSS, AMOS, and ArcGIS, enabling him to conduct sophisticated data analysis, structural equation modeling, and spatial mapping.

Teaching and Mentoring Experience

While not explicitly documented in formal teaching roles, Mr. Sapkota’s research assistantships have included mentoring junior researchers, organizing bioassay procedures, and contributing to structured data collection training among field staff. These informal capacities demonstrate leadership and the potential for future academic mentoring and teaching positions.

Legacy and Future Contributions

He is well-positioned to make impactful contributions in sustainable agriculture, environmental toxicology, and computational modeling of pesticide risks. His research bridges the urgent need for ecological safety with scientifically validated pest management strategies. As agricultural systems evolve to meet climate challenges, researchers like Mr. Sapkota are essential in designing interventions that are biologically sound, environmentally friendly, and socioeconomically viable.

His interdisciplinary training across field research, molecular diagnostics, and behavioral science will enable him to lead cross-sectoral initiatives in agricultural development, public health, and ecological conservation. With a firm foundation in both theory and application, he is prepared to engage with global research communities, drive regional development programs, and contribute to peer-reviewed publications and international conferences.

Notable Publications

  • Farmers’ Behavioral Intention Towards Pesticide Safety in Nepal: An Assessment of the Extended Theory of Planned Behavior
    Authors: Utkal Sapkota, Sarmila Adhikari, Govinda Bhandari
    Journal: Journal of Environmental Management
    Year: 2025

  • Pesticide Use and Safety Behavior Among Rice Farmers in Nepal: The Assessment of Theory of Planned Behavior and Potential Health Risk
    Authors: Govinda Bhandari, Anushka Pandey, Utkal Sapkota, Sheelendra Pratap Singh, Hirotatsu Murano
    Journal: Environment, Development and Sustainability
    Year: 2025

  • Modeling Vegetable Farmers’ Intention to Use Pesticides in Central Nepal: An Extended Version of the Planned Behavior Theory
    Authors: Utkal Sapkota, Govinda Bhandari, Mandira Sapkota, Sneha Khanal, Asmita Poudel, Dipak Khanal, Min Raj Pokhrel, Christos A. Damalas
    Journal: Environmental Challenges
    Year: 2025

  • Safety Behavior of Nepalese Strawberry Farmers as Reflected by the Protection Motivation Theory
    Authors: Utkal Sapkota, Govinda Bhandari, Lalit BC, Liangxin Fan, Violette Geissen
    Journal: International Journal of Environmental Research
    Year: 2025

Conclusion

He represents a new generation of scientifically rigorous, environmentally aware researchers whose academic path and research focus reflect a commitment to solving pressing agricultural and environmental challenges. Through integrated methodologies, strong technical expertise, and a clear vision for sustainable development, he is set to contribute meaningfully to the advancement of agroecological research, environmental safety, and rural transformation in Nepal and beyond.

Eva Choong | Analytical Chemistry | Women Researcher Award

Dr. Eva Choong | Analytical Chemistry | Women Researcher Award

CHUV – Hôpital Universitaire, Switzerland

👨‍🎓Profiles

🎓 Early Academic Pursuits

Dr. Eva Choong began her academic journey at the University of Lausanne, where she earned her Swiss Federal Diploma in Pharmacy from the Lausanne School of Pharmacy, Department of Sciences (1997–2002). Her interest in the interplay between pharmacology and patient care led her to pursue a PhD in Pharmaceutical Sciences at the University of Geneva (2006–2011), with a thesis on “Clinical and pharmacogenetic studies on response and side effects of psychotropic drugs.” Supervised by Prof. C.B. Eap and co-supervised by Prof. J-L. Veuthey, her doctoral work was honored with highest distinctions, showcasing her early dedication to clinical research and analytical chemistry.

👩‍⚕️ Professional Endeavors

Dr. Choong’s post-doctoral career commenced at the Pharmacogenetics Unit within the Department of Physiology and Pharmacology (2011–2014), where she explored the genetic basis of drug metabolism. From 2015 to mid-2016, she held the role of Senior Scientist (Maître-Assistante) at the University of Geneva’s Pediatric Oncology and Hematology Research Platform, working with Prof. M. Ansari. Since August 2016, she has served as Laboratory Deputy and Scientific Expert in the Laboratory of Clinical Pharmacology at CHUV (Centre Hospitalier Universitaire Vaudois), under the leadership of Prof. L.A. Decosterd, contributing to both operational oversight and high-impact research.

🧪 Contributions and Research Focus

Dr. Choong has made significant contributions to the field of clinical pharmacology, with particular emphasis on therapeutic drug monitoring (TDM), analytical method development, and pharmacogenetics. Her research focuses on optimizing drug therapies for various conditions, notably in infectious diseases and cystic fibrosis, by measuring drug concentrations in biological matrices using LC-MS/MS methods validated to ISO15189:2022 standards. At CHUV, her laboratory is responsible for monitoring over 130 drugs for clinical application and research across Swiss university hospitals.

🌍 Impact and Influence

Dr. Choong’s work has had a lasting impact in bridging the gap between clinical pharmacology and personalized medicine. Her role in developing mass spectrometry-based drug monitoring protocols has influenced treatment paradigms for cystic fibrosis and HIV. She is also a key contributor to collaborative projects such as the Swiss HIV Cohort Study, and has worked with major pharmaceutical entities like Incyte Biosciences to ensure external quality controls in TDM assays. Her expertise is widely recognized within the Swiss medical research community.

📚 Academic Citations and Recognitions

Dr. Choong is the recipient of several prestigious grants and awards, including: Principal Investigator, Cystic Fibrosis Switzerland Foundation Grant (2022, 30,000 CHF); Partner, Swiss National Science Foundation Grant (2022, 643,365 CHF); Lead recipient, Incyte Biosciences grant (2019–2021, 80,000 CHF); Awardee, Lundbeck Institute Prize in Psychiatry (2014); Grantee, NCCR Synapsys (2013); and recipient of two Early Postdoc.Mobility fellowships (2012 & 2013, combined over 65,000 CHF). These accolades attest to her scientific excellence, thought leadership, and the high citation value of her research in peer-reviewed domains.

🛠️ Technical Skills

Dr. Choong is proficient in a range of analytical and clinical methodologies, including: LC-MS and LC-MS/MS in ISO15189-accredited environments; validation of bioanalytical methods for therapeutic monitoring; pharmacokinetics and pharmacogenetics analysis; biostatistics, clinical epidemiology, and regulatory compliance under Swissethics. Her training includes completion of management programs for medical professionals, allowing her to seamlessly integrate leadership and science in hospital and academic settings.

👩‍🏫 Teaching Experience and Mentorship

Throughout her career, Dr. Choong has demonstrated a strong commitment to mentoring junior researchers and medical professionals. Her involvement in training programs, supervision of postgraduates, and contribution to interdisciplinary education at CHUV and the University of Geneva underscores her dedication to the academic and clinical advancement of future professionals in pharmacology and biomedicine.

🌟 Legacy and Future Contributions

With a career rooted in precision medicine, analytical innovation, and translational research, Dr. Choong continues to play a central role in transforming clinical pharmacology in Switzerland. Her ongoing projects aim to expand the utility of mass spectrometry for real-time therapeutic monitoring, develop novel biomarkers, and refine treatment regimens for complex patient populations such as those affected by cystic fibrosis and HIV. As a respected scientific leader, her legacy will be marked by both the technical excellence of her lab and her unwavering commitment to patient-centered innovation.

📖Notable Publications

A Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Cystic Fibrosis Drugs (Caftors) in Plasma and Its Application for Therapeutic Monitoring
Authors: Valentina D’Atri, Fabrizio Corrado, François Versace, Susana Alves Saldanha, Thomas Mercier, Guidi Monia, Paul Thoueille, Sylvain Blanchon, Angela Koutsokera, Michael Vogeser et al.
Journal: Molecules
Year: 2025

Population Pharmacokinetics of Cabotegravir Following Oral Administration and Long-Acting Intramuscular Injection in Real-World People with HIV
Authors: Thoueille P., Saldanha S.A., Schaller F., Choong E., Veuve F., Munting A., Cavassini M., Braun D., Günthard H.F., Duran Ramirez J.J. et al.
Journal: Clinical Pharmacology & Therapeutics
Year: 2024

Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC-MS/MS) Methods for the Therapeutic Drug Monitoring of Cytotoxic Anticancer Drugs: An Update
Authors: Briki M., Murisier A., Guidi M., Seydoux C., Buclin T., Marzolini C., Girardin F.R., Thoma Y., Carrara S., Choong E. et al.
Journal: Journal of Chromatography B
Year: 2024

Real-World Trough Concentrations and Effectiveness of Long-Acting Cabotegravir and Rilpivirine: A Multicenter Prospective Observational Study in Switzerland
Authors: Thoueille P., Saldanha S.A., Schaller F., Choong E., Munting A., Cavassini M., Braun D., Günthard H.F., Kusejko K., Surial B. et al.
Journal: The Lancet Regional Health – Europe
Year: 2024

Development and Validation of a Multiplex HPLC-MS/MS Assay for the Monitoring of JAK Inhibitors in Patient Plasma
Authors: Tachet J., Versace F., Mercier T., Buclin T., Decosterd L.A., Choong E., Girardin F.R.
Journal: Journal of Chromatography B
Year: 2023