Ruoxuan Sun | Immunogenicity of Biotherapeutics | Best Researcher Award

Dr. Ruoxuan Sun | Immunogenicity of Biotherapeutics | Best Researcher Award

Takeda Pharmaceutical, United States

๐Ÿ‘จโ€๐ŸŽ“Profiles

๐ŸŽ“ Early Academic Pursuits

He began their academic journey at Peking University, earning a Bachelor of Science (B.S.) in Pharmaceutical Sciences. Building upon this foundation, they pursued a Master of Science (M.S.) in the same discipline, demonstrating exceptional research capabilities. Continuing their academic excellence, Sun completed a Ph.D. in Pharmacy at Purdue University, where they delved into groundbreaking studies on immunotherapy and molecular biology.

๐Ÿ’ผ Professional Endeavors

Currently serving as a Research Senior Scientist at Takeda Pharmaceuticals in Cambridge, MA, He has been with the compan, ascending from Research Scientist I to their present senior role. Their responsibilities include: Anti-drug antibody (ADA) assay development for pre-clinical studies, Innovative wash-free platforms for bioanalysis using NanoBiT and fluorescence polarization strategies, Epitope profiling and immunogenicity risk assessment for novel therapeutic modalities, In silico and in vitro immunogenicity evaluations to assess and mitigate immunogenicity risks in large molecules and biotherapeutics.

๐Ÿงช Contributions and Research Focus

His research at Takeda and Purdue University spans a wide array of scientific domains: ADA assay innovations for therapeutic candidates such as antibodies, oligonucleotides, and lipid nanoparticles, Epitope mapping strategies to assess immunogenicity and optimize therapeutic candidates, Post-translational modification regulation of immune receptors, including the identification of FBXL20 as a regulator of 4-1BB, Cancer immunotherapy development, focusing on glycosylation targeting and immunotherapy combinations.

๐ŸŒ Impact and Influence

He has significantly influenced the fields of immunogenicity, bioanalysis, and cancer therapy through innovative research and industrial contributions. Their work has informed drug development processes, improved assay platforms, and expanded understanding of immunogenicity risks in preclinical and clinical studies.ย As a journal reviewer for esteemed publications like Redox Biology and Biomarker Research, Sun has contributed to the dissemination of high-quality research in their field.

๐Ÿ“ˆ Academic Cites and Achievements

During their academic career, Sun authored pivotal publications focusing on the regulation of 4-1BB and cancer immunotherapy. Their impactful work has been recognized within the scientific community, leading to high citation metrics and collaborations with leading researchers.

๐Ÿ› ๏ธ Technical Skills

He possesses a versatile skill set, blending expertise in immunogenicity assessment, molecular and cellular biology, biochemistry, and computational biology. Key proficiencies include: Development and validation of ADA and biomarker assays, Advanced protein purification and molecular cloning techniques, In silico modeling using platforms like Alphafold to predict immunogenicity.

๐Ÿ“š Teaching Experience

As a Graduate Teaching Assistant at Purdue University, He contributed to multiple academic disciplines: Organic Chemistry II Lab, Human Anatomy and Physiology Lab, Immunology, Integrated Pharmacotherapy. Their teaching fostered a new generation of pharmaceutical scientists, emphasizing practical skills and theoretical understanding.

๐ŸŒŸ Legacy and Future Contributions

His pioneering work in immunogenicity risk assessment and bioanalysis platform development has paved the way for safer and more effective therapeutic modalities. Looking ahead, Sun aims to further advance innovations in biotherapeutics, leveraging cutting-edge techniques and computational tools to address emerging challenges in drug development.

๐Ÿ“–Notable Publications

  1. Corrigendum to โ€œThe antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselenโ€
    • Authors: Zheng, X., Chen, Y., Bai, M., Sun, R., Zeng, H.
    • Journal: Free Radical Biology and Medicine
    • Year: 2021
  1. Corrigendum to โ€˜Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activityโ€™
    • Authors: Zheng, X., Ma, W., Sun, R., Xu, W., Zeng, H.
    • Journal: Redox Biology
    • Year: 2020
  1. Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study
    • Authors: Ye, S., Chen, X., Yao, Y., Shu, Y., Yin, H.
    • Journal: Scientific Reports
    • Year: 2019
  1. The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen
    • Authors: Zheng, X., Chen, Y., Bai, M., Sun, R., Zeng, H.
    • Journal: Free Radical Biology and Medicine
    • Year: 2019
  1. Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity
    • Authors: Zheng, X., Ma, W., Sun, R., Xu, W., Zeng, H.
    • Journal: Redox Biology
    • Year: 2018
  1. Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells
    • Authors: Zheng, X., Xu, W., Sun, R., Dong, C., Zeng, H.
    • Journal: Chemico-Biological Interactions
    • Year: 2017
  1. Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress
    • Authors: Dong, C., Zhang, L., Sun, R., Zheng, X., Zeng, H.
    • Journal: Scientific Reports
    • Year: 2016
  1. Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation
    • Authors: Zheng, X., Zhang, Y., Zhang, L., Sun, R., Zeng, H.
    • Journal: Biomedicine and Pharmacotherapy
    • Year: 2016

ลžengรผl Alpay KaraoฤŸlu | Molecular Biology | Women Researcher Award

Prof Dr. ลžengรผl Alpay KaraoฤŸlu | Molecular Biology | Women Researcher Award

Recep Tayyip ErdoฤŸan University, Turkey

ย Profiles๐Ÿ‘จโ€๐ŸŽ“

ย Early Academic Pursuits๐ŸŽ“

Prof. Dr. Sengul Alpay Karaoglu's academic foundation is grounded in Microbial Physiology, earning her MSc in 2015-2016 from Recep Tayyip ErdoฤŸan University. Her early focus included critical areas such as General Microbiology, Virology, Immunology, and Molecular Biology and Genetics. Over time, she has expanded her expertise into Biotechnology, Biodiversity Conservation, Pharmacology, and Mycology. Her solid academic background laid the groundwork for her substantial contributions in microbial and environmental sciences.

ย Professional Endeavors๐Ÿ’ผ

She has held multiple influential academic roles at Recep Tayyip ErdoฤŸan University, including Faculty Board Member (2015โ€“2022) and Head of the Biology Department (2016โ€“present). She was also appointed Professor at GรผmรผลŸhane University in 2022. Her academic career spans two decades of service, where she has actively contributed to curriculum development and academic leadership in Biology, Microbiology, and Mycology. Beyond administrative roles, she is a patent holder and has led numerous research projects, showcasing her multidisciplinary talents in both teaching and research.

ย Contributions and Research Focus๐Ÿ”ฌ

Her research portfolio is rich with innovative work across microbiology, pharmacology, and biotechnology. Her research has notably contributed to understanding antimicrobial drugs and microbial biodiversity. Major highlights include: Antimicrobial properties of lactic acid bacteria isolated from honeybees (Apis mellifera), Characterization of Bacillus species and their bioactive metabolites, including antifungal and antibacterial activities, Studies on antibiotic resistance in Escherichia coli strains and molecular identification of Trichoderma species for biological control.

Her research contributions are reflected in several peer-reviewed publications and patents, such as her invention on an anti-helicobacter effective azo dye and urease enzyme inhibitor. Her work on synthesizing Penicillin-, Cephalosporin-, and Norfloxacin-Azole hybrid molecules demonstrates her role in advancing antimicrobial drug design.

ย Impact and Influence๐ŸŒ

Her impact on the scientific community is wide-reaching, particularly in microbiology and biotechnology. Her TรœBฤฐTAK projects and work with higher education institutions underscore her leadership in addressing critical environmental and agricultural challenges. The innovative nature of her research has implications for antimicrobial therapies, environmental microbiology, and pharmacology, helping shape global understanding in these fields.

ย Academic Cites and Recognition๐Ÿ“š

Her research output has been widely cited in scientific journals and conferences, contributing to her reputation as a leading academic in Turkey and beyond. Her studies have enhanced the scientific understanding of antibiotic resistance and biological control mechanisms.

Technical Skills๐Ÿ› ๏ธ

Prof. Karaogluโ€™s technical expertise spans advanced microbiological techniques, including microbial culturing, genetic sequencing, molecular biology assays, and biotechnological applications. Her ability to blend laboratory research with real-world environmental applications is a hallmark of her technical acumen.

Teaching Experience๐Ÿ‘ฉโ€๐Ÿซ

She has an extensive teaching career, offering courses across several key fields, including: Molecular Cell Biology, Environmental Biotechnology, Food Microbiology, Virology. Antimicrobial Drugs and Their Mechanisms of Action Her commitment to academic excellence is demonstrated through her management of multiple graduate theses, mentoring students in cutting-edge microbiological research.

Legacy and Future Contributions๐Ÿ†

Her legacy is one of scientific innovation and educational leadership. As a professor and researcher, she has not only contributed to critical advancements in microbiology and pharmacology but also nurtured the next generation of scientists. Moving forward, her work in biotechnology, antimicrobial resistance, and environmental microbiology will continue to be pivotal in addressing global scientific challenges. Prof. Karaogluโ€™s extensive portfolio ensures her lasting influence on both academia and the scientific community.

Notable Publications๐Ÿ“–

"Characterization of chitin and description of its antimicrobial properties obtained fromย Cydalima perspectalisย adults"

Authors: Kฤฑlcฤฑ, L., Altun, N., KaraoฤŸlu, ลž.A., Karaduman YeลŸildal, T.

Journal:ย Polymer Bulletin

Year: 2024

"Prevalence and Phylogenetic Network Analysis ofย Nosema apisย andย Nosema ceranaeย Isolates from Honeybee Colonies in Tรผrkiye"

Authors: Akpฤฑnar, R.K., Gรผrler, A.T., BรถlรผkbaลŸ, C.S., KรผรงรผkoฤŸlu, B., Kurt, M.

Journal:ย Acta Parasitologica

Year: 2024

"Prevalence and molecular analysis of some important viruses in honey bee colonies in Tรผrkiye: the status of multiple infections"

Authors: Akpinar, R., Ozan, E., Celik, S., Yaldiz, M., Karaoglu, S.A.

Journal:ย Archives of Virology

Year: 2024

"Synthesis, Antimicrobial Activities, and Molecular Modeling Studies of Agents for the Sortase A Enzyme"

Authors: Tatar Yilmaz, G., Yayli, N., Tรผzรผner, T., Bozdeveci, A., Alpay KaraoฤŸlu, ลž.

Journal:ย Chemistry and Biodiversity

Year: 2024

"Determination of plant growth promoting properties and bioremediation potentials ofย Bacillus mycoidesย Flรผgge andย B. thuringiensisย Berliner"

Authors: รœreyen EsertaลŸ, รœ.Z., Bozdeveci, A., UzunalioฤŸlu, E., Alpay KaraoฤŸlu, ลž.

Journal:ย Trakya University Journal of Natural Sciences

Year: 2024

"Some Schiff Bases Containing Eugenol and Guaiacol: Comparison of Urease Inhibition and Anti-Helicobacter pylori Activities with Its Azo Analogs"

Authors: Kantar, C., BaltaลŸ, N., KaraoฤŸlu, ลž.A., ลžaลŸmaz, S.

Journal:ย Pharmaceutical Chemistry Journal

Year: 2024