Ruoxuan Sun | Immunogenicity of Biotherapeutics | Best Researcher Award

Dr. Ruoxuan Sun | Immunogenicity of Biotherapeutics | Best Researcher Award

Takeda Pharmaceutical, United States

👨‍🎓Profiles

🎓 Early Academic Pursuits

He began their academic journey at Peking University, earning a Bachelor of Science (B.S.) in Pharmaceutical Sciences. Building upon this foundation, they pursued a Master of Science (M.S.) in the same discipline, demonstrating exceptional research capabilities. Continuing their academic excellence, Sun completed a Ph.D. in Pharmacy at Purdue University, where they delved into groundbreaking studies on immunotherapy and molecular biology.

💼 Professional Endeavors

Currently serving as a Research Senior Scientist at Takeda Pharmaceuticals in Cambridge, MA, He has been with the compan, ascending from Research Scientist I to their present senior role. Their responsibilities include: Anti-drug antibody (ADA) assay development for pre-clinical studies, Innovative wash-free platforms for bioanalysis using NanoBiT and fluorescence polarization strategies, Epitope profiling and immunogenicity risk assessment for novel therapeutic modalities, In silico and in vitro immunogenicity evaluations to assess and mitigate immunogenicity risks in large molecules and biotherapeutics.

🧪 Contributions and Research Focus

His research at Takeda and Purdue University spans a wide array of scientific domains: ADA assay innovations for therapeutic candidates such as antibodies, oligonucleotides, and lipid nanoparticles, Epitope mapping strategies to assess immunogenicity and optimize therapeutic candidates, Post-translational modification regulation of immune receptors, including the identification of FBXL20 as a regulator of 4-1BB, Cancer immunotherapy development, focusing on glycosylation targeting and immunotherapy combinations.

🌍 Impact and Influence

He has significantly influenced the fields of immunogenicity, bioanalysis, and cancer therapy through innovative research and industrial contributions. Their work has informed drug development processes, improved assay platforms, and expanded understanding of immunogenicity risks in preclinical and clinical studies. As a journal reviewer for esteemed publications like Redox Biology and Biomarker Research, Sun has contributed to the dissemination of high-quality research in their field.

📈 Academic Cites and Achievements

During their academic career, Sun authored pivotal publications focusing on the regulation of 4-1BB and cancer immunotherapy. Their impactful work has been recognized within the scientific community, leading to high citation metrics and collaborations with leading researchers.

🛠️ Technical Skills

He possesses a versatile skill set, blending expertise in immunogenicity assessment, molecular and cellular biology, biochemistry, and computational biology. Key proficiencies include: Development and validation of ADA and biomarker assays, Advanced protein purification and molecular cloning techniques, In silico modeling using platforms like Alphafold to predict immunogenicity.

📚 Teaching Experience

As a Graduate Teaching Assistant at Purdue University, He contributed to multiple academic disciplines: Organic Chemistry II Lab, Human Anatomy and Physiology Lab, Immunology, Integrated Pharmacotherapy. Their teaching fostered a new generation of pharmaceutical scientists, emphasizing practical skills and theoretical understanding.

🌟 Legacy and Future Contributions

His pioneering work in immunogenicity risk assessment and bioanalysis platform development has paved the way for safer and more effective therapeutic modalities. Looking ahead, Sun aims to further advance innovations in biotherapeutics, leveraging cutting-edge techniques and computational tools to address emerging challenges in drug development.

📖Notable Publications

  1. Corrigendum to “The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen”
    • Authors: Zheng, X., Chen, Y., Bai, M., Sun, R., Zeng, H.
    • Journal: Free Radical Biology and Medicine
    • Year: 2021
  1. Corrigendum to ‘Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity’
    • Authors: Zheng, X., Ma, W., Sun, R., Xu, W., Zeng, H.
    • Journal: Redox Biology
    • Year: 2020
  1. Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study
    • Authors: Ye, S., Chen, X., Yao, Y., Shu, Y., Yin, H.
    • Journal: Scientific Reports
    • Year: 2019
  1. The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen
    • Authors: Zheng, X., Chen, Y., Bai, M., Sun, R., Zeng, H.
    • Journal: Free Radical Biology and Medicine
    • Year: 2019
  1. Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity
    • Authors: Zheng, X., Ma, W., Sun, R., Xu, W., Zeng, H.
    • Journal: Redox Biology
    • Year: 2018
  1. Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells
    • Authors: Zheng, X., Xu, W., Sun, R., Dong, C., Zeng, H.
    • Journal: Chemico-Biological Interactions
    • Year: 2017
  1. Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress
    • Authors: Dong, C., Zhang, L., Sun, R., Zheng, X., Zeng, H.
    • Journal: Scientific Reports
    • Year: 2016
  1. Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation
    • Authors: Zheng, X., Zhang, Y., Zhang, L., Sun, R., Zeng, H.
    • Journal: Biomedicine and Pharmacotherapy
    • Year: 2016

Haowen Huang | Chemical and Bioanalysis | Best Researcher Award

Prof. Haowen Huang | Chemical and Bioanalysis | Best Researcher Award

Hunan University of Science and Technology, China

👨‍🎓Profile

🎓 Early Academic Pursuits

Haowen Huang earned his Ph.D. in Analytical Chemistry from the Institute of Chemistry, Chinese Academy of Sciences, in 2004, following his M.S. in Analytical Chemistry from Hunan University in 1999. His early academic journey laid a strong foundation in analytical chemistry, with a focus on the development of advanced chemical and biosensing methods.

👨‍🏫 Professional Endeavors

He is currently a Professor at the School of Chemistry and Chemical Engineering at Hunan University of Science and Technology, a position he has held since 2011. Prior to this, he served as an Associate Professor at the same institution from 2006 to 2011. His professional career is marked by a commitment to advancing the field of analytical chemistry, particularly in the development of novel biosensors and nanomaterials.

🔬 Contributions and Research Focus

His research primarily focuses on the development of biosensors and analytical platforms using noble metal nanomaterials, such as gold nanoparticles, nanoclusters, and carbon dots, for the detection of biomolecules like proteins, nucleic acids, and small molecules. He has also worked extensively on surface plasmon resonance (SPR) systems, applying SPR imaging to enhance molecular recognition capabilities. His work in nanomaterials and advanced analytical techniques plays a key role in applications across biomedical diagnostics, environmental monitoring, and single-cell analysis.

🌍 Impact and Influence

His contributions have had a significant impact on the fields of analytical chemistry and biosensor development. His pioneering work with gold nanorods and nanoclusters for multiplex detection of disease markers and heavy metals has positioned him as a leader in the field. Additionally, his developments in SPR imaging systems have advanced chiral recognition and biomolecular interaction studies, further enhancing the molecular diagnostics landscape.

📚 Academic Cites

Although specific citation numbers are not provided, Dr. Huang's research has been widely acknowledged in the scientific community, evidenced by his work's application in major areas of biosensing, diagnostics, and environmental monitoring. His work continues to influence new developments in the synthesis and application of nanomaterials.

🛠️ Technical Skills

He is an expert in the synthesis and characterization of nanomaterials, particularly gold and carbon-based nanoclusters. He is highly proficient in the fabrication of optical biosensors and in the use of surface plasmon resonance imaging systems. His expertise extends to the development of advanced analytical methods for complex biological media, which is crucial for a variety of applications in diagnostics and environmental monitoring.

📚 Teaching Experience

As a professor, He teaches courses in Analytical Chemistry and Instrumental Analysis, in addition to supervising laboratory courses. He mentors graduate and undergraduate students, guiding research projects that focus on the synthesis of nanomaterials and their application in biosensor development. His teaching fosters innovation in the next generation of researchers in the fields of analytical chemistry and biosensing technologies.

🏆 Legacy

His legacy lies in his contributions to the development of cutting-edge biosensor technologies and nanomaterial applications. His work has shaped the field of molecular detection and bioanalytics, particularly in terms of how nanomaterials can be integrated into diagnostic tools for disease detection and environmental monitoring.

🔮 Future Contributions

Looking ahead, He is poised to continue his groundbreaking work in the development of next-generation biosensors and analytical techniques. His research will likely advance the use of nanomaterials in precision medicine, single-cell analysis, and real-time environmental monitoring. His expertise in SPR imaging and nanomaterials synthesis is expected to drive further innovation in these rapidly evolving fields.

📖Notable Publications