Sourav De | Medicinal Chemistry | Best Researcher Award

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Dr. Sourav De | Medicinal Chemistry | Best Researcher Award

Eminent College of Pharmaceutical Technology, India

👨‍🎓Profiles

🎓 Education and Academic Background

Dr. Sourav De is a distinguished researcher and educator currently affiliated with Eminent College of Pharmaceutical Technology, India. He earned his Doctor of Philosophy (Ph.D.) in Chemistry from the School of Advanced Sciences, Vellore Institute of Technology (VIT), India (March 2017 – December 2020). Under the guidance of Dr. S. K. Ashok Kumar, Professor, his doctoral thesis focused on the design, synthesis, characterization, and anticancer evaluation of various heterocycles and Ru(II)-arene-N^N, N^O, N^S complexes. His strong academic foundation also includes an M.Pharm in Pharmaceutical Chemistry from West Bengal University of Technology (2010–2012), where he graduated with a CGPA of 8.79 (First Class), and a B.Pharm from the University of North Bengal (2006–2010), securing 74% (First Class).

🔬 Research Interests

Dr. Sourav De’s research interests span a diverse range of medicinal chemistry and organometallic chemistry, with a strong emphasis on the therapeutic applications of organic and organometallic complexes. His key areas of focus include: Molecular Modeling and In-Silico Studies for drug discovery and computational chemistry. Chromogenic and Fluorogenic Sensors for biomedical and pharmaceutical applications. Cancer Research, particularly in the treatment of cervical, colon, breast, and brain tumors.

🏆 Research Projects

Dr. De has actively contributed to multiple academic research and technology development projects, showcasing his expertise in cancer theranostics, drug discovery, and molecular design. Notable projects include: DST-SERB Sponsored Project: He worked as a Project Assistant on the Development of novel 2-aryl benzothiazole/benzoxazole, quinoxaline, and phenanthroline analogues as fluorescent probes and cancer theranostics applications (EMR/2017/000816). Grant-in-Aid SEED Fund Research Project: As a Principal Investigator, he led a research project titled “In silico analysis of some ruthenium complexes as potential anti-cancer agents,” funded by Rs. 85,000 (AU/REG/NOT/2021/04/003). With over 11 years and 9 months of research experience, Dr. De has made impactful contributions to the fields of drug development and computational chemistry.

🛠️ Technical Skills

Dr. Sourav De possesses strong technical expertise across various analytical instruments, imaging techniques, and computational tools. His skill set includes: Instruments Handled: UV, FL, FTIR, CD spectroscopy, ELISA reader, Gel Doc, and HPLC. Imaging Techniques: Fluorescent Microscopy, Scanning Electron Microscopy (SEM), and Flow Cytometry. Computational and Analytical Tools: Molecular Modeling & Docking: AutoDock 4.2, AutoDock Vina, Chimera 1.11rc, Open Babel GUI. Data Analysis: Python for scientific computing and data visualization. Plotting and Molecular Visualization: Origin, ChemDraw, ChemSketch. Hands-on Experience: Cell culture, molecular biology, and bioinformatics for drug-target interactions and cancer research.

📚 Teaching Experience

Dr. De is an experienced educator specializing in pharmaceutical and medicinal chemistry. He has taught various subjects, including: Pharmaceutical Chemistry & Medicinal Chemistry, Organic and Inorganic Chemistry, Pharmaceutical Analysis & Instrumental Analysis. His teaching methodology combines practical applications and research-driven insights, ensuring students gain both theoretical knowledge and hands-on experience.

🌟 Future Research and Contributions

Dr. Sourav De is committed to advancing therapeutic drug design, molecular diagnostics, and cancer research. His future work aims to develop targeted anticancer drugs, bioactive organometallic complexes, and AI-driven molecular modeling techniques. With his expertise in pharmaceutical sciences and computational chemistry, he continues to make significant contributions to drug discovery and medicinal research.

📖Notable Publications

  • Pyridine: the scaffolds with significant clinical diversity

    • Authors: S De, AK SK, SK Shah, S Kazi, N Sarkar, S Banerjee, S Dey
    • Journal: RSC Advances
    • Year: 2022

  • Critical role of dipeptidyl peptidase IV: a therapeutic target for diabetes and cancer

    • Authors: S De, S Banerjee, SKA Kumar, P Paira
    • Journal: Mini Reviews in Medicinal Chemistry
    • Year: 2019

  • Synthesis, characterisation, molecular docking, biomolecular interaction and cytotoxicity studies of novel ruthenium (II)–arene-2-heteroarylbenzoxazole complexes

    • Authors: S De, SR Chaudhuri, A Panda, GR Jadhav, RS Kumar, P Manohar, …
    • Journal: New Journal of Chemistry
    • Year: 2019

  • Amberlite IR-120 (H) mediated “on water” synthesis of fluorescent Ruthenium (II)-arene 8-hydroxyquinoline complexes for cancer therapy and live cell imaging

    • Authors: A Mondal, S De, S Maiti, B Sarkar, AK Sk, R Jacob, A Moorthy, P Paira
    • Journal: Journal of Photochemistry and Photobiology B: Biology
    • Year: 2018

  • Luminescent ruthenium (II)-para-cymene complexes of aryl substituted imidazo-1,10-phenanthroline as anticancer agents and the effect of remote substituents on cytotoxic activities

    • Authors: S De, RS Kumar, A Gauthaman, SKA Kumar, P Paira, A Moorthy, …
    • Journal: Inorganica Chimica Acta
    • Year: 2021

Natalya Kurochkina | Protein Structure | Best Researcher Award – 1648

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Dr. Natalya Kurochkina | Protein Structure | Best Researcher Award

The School of Theoretical Modeling, United States

👨‍🎓Profiles

Early Academic Pursuits 🎓

Natalya Kurochkina’s academic journey began when she earned her Ph.D. in Biophysics at the Institute of Protein Research, Russian Academy of Sciences. Her postdoctoral work followed in 1991 at the National Cancer Institute of the National Institutes of Health in Bethesda, USA, focusing on Biochemistry. These formative years laid the foundation for her expertise in protein structure and biophysical analysis.

Professional Endeavors 💼

After her postdoctoral studies, Kurochkina worked as a Research Scientist at Applied Thermodynamics in Hunt Valley, MD, between 1996 and 1998. In 1998, she established the School of Theoretical Modeling in Washington, DC, where she has since served as a Professor of Biophysics. She teaches courses in Biomedical Research and Protein Modeling, contributing significantly to the academic development of students in these fields. Her research has focused on the structure and dynamics of proteins, particularly in the context of medical applications.

Contributions and Research Focus 🔬

Kurochkina’s research contributions are substantial and have made a significant impact on the field of biophysics and biochemistry. She developed methods for predicting protein conformation, including novel approaches to designing immunotoxins. Her work on the molecular modeling of various medically relevant proteins, such as fibrin, UDP-GlcNAc 2-epimerase/ManNAc kinase, and TRP1/TRPV1/CDK5, has advanced the understanding of these molecules. Kurochkina also pioneered studies into the structural determinants of protein assembly and the impact of helix interfaces on ligand binding.

Impact and Influence 🌍

Kurochkina’s work has not only contributed to the scientific community but also has tangible medical implications. Her design of immunotoxins and modeling of critical proteins has advanced therapeutic approaches for various diseases. Additionally, her research in protein structure analysis is essential for understanding disease-related mutations, such as those linked to hereditary conditions like HSAN2A and sialuria. Her innovations have drawn attention globally, and her publications are regularly cited within the scientific literature.

Academic Cites 📚

Kurochkina has published 30 journals in high-impact databases like SCI and Scopus, with a citation index of 14. Her research is widely recognized within the biophysics and protein modeling communities. As a key contributor to multiple fields, her work on the structural and functional aspects of proteins continues to be referenced by experts and researchers worldwide.

Technical Skills 🛠️

Kurochkina possesses advanced technical skills in protein modeling, biophysical analysis, and computational chemistry. Her expertise includes structural modeling of proteins, secondary structure analysis, and the prediction of amino acid interactions. She has also worked extensively with molecular modeling software to simulate and predict the behavior of protein assemblies, particularly in the context of disease-associated mutations.

Teaching Experience 👩‍🏫

As a Professor of Biophysics, Kurochkina has mentored and shaped the careers of many students. Her teaching experience spans biomedical research, protein modeling, and the theoretical foundations of molecular biology. She is known for her ability to inspire students and foster a deep understanding of biophysics. Her guidance in both academic and research settings has been instrumental in the development of the next generation of scientists.

Legacy and Future Contributions 🔮

Kurochkina’s legacy is marked by her groundbreaking contributions to protein structure prediction and her innovations in immunotoxin design. Her future research aims to further explore the complexities of protein dynamics and their role in disease. She continues to focus on developing computational tools that enhance the understanding of protein behavior in various biological systems. Her work promises to continue influencing the fields of biophysics, biochemistry, and biomedical research for years to come.

📖Notable Publications

Expression pattern analysis and characterization of the hereditary sensory and autonomic neuropathy 2 A (HSAN2A) gene with no lysine kinase (WNK1) in human dorsal root ganglion

Authors: Sapio, M.R., King, D.M., Staedtler, E.S., Mannes, A.J., Iadarola, M.J.
Journal: Experimental Neurology
Year: 2023

Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception

Authors: Hall, B.E., Prochazkova, M., Sapio, M.R., Iadarola, M.J., Kulkarni, A.B.
Journal: Scientific Reports
Year: 2018

Phosphorylation, Dephosphorylation, and Multiprotein Assemblies Regulate Dynamic Behavior of Neuronal Cytoskeleton: A Mini-Review

Authors: Kurochkina, N., Bhaskar, M., Yadav, S.P., Pant, H.C.
Journal: Frontiers in Molecular Neuroscience
Year: 2018

Helical assemblies: Structure determinants

Authors: Kurochkina, N.A., Iadarola, M.J.
Journal: Journal of Theoretical Biology
Year: 2015