Genentech, Inc., United States
👨🎓Profiles
🎓 Early Academic Pursuits
Dr. Nicholas A. White’s passion for chemistry began during his undergraduate years at Loyola University Chicago, where he earned a B.S. in Chemistry, graduating magna cum laude in 2010. During this time, he conducted research under Prof. James Babler, focusing on chemoselective Ru(III)/NaBH4 reductions. He further advanced his academic career by pursuing a Ph.D. in Chemistry at Colorado State University under Prof. Tomislav Rovis, specializing in asymmetric N-heterocyclic carbene-catalyzed reactions.
💼 Professional Endeavors
Dr. White is currently a Sr. Principal Scientist in the Department of Synthetic Molecule Process Chemistry at Genentech, Inc., where he leads the development of innovative and phase-appropriate processes for producing high-quality Active Pharmaceutical Ingredients (APIs). His industry experience also includes a formative internship at TOLMAR Pharmaceuticals, where he contributed to pharmaceutical manufacturing and process development.
🔬 Contributions and Research Focus
Throughout his career, Dr. White has contributed to advancing synthetic organic chemistry, with a particular emphasis on catalysis and process chemistry. His postdoctoral work at MIT with Prof. Stephen L. Buchwald was centered on developing Pd-catalyzed C–N couplings using amine bases, providing valuable methodologies for pharmaceutical synthesis.
🌍 Impact and Influence
At Genentech, Dr. White’s work directly supports the delivery of safe and effective medicines. His ability to translate cutting-edge synthetic chemistry into scalable, robust manufacturing processes plays a key role in the company’s mission to bring novel therapeutics to patients.
🧪 Technical Skills
Dr. White has a diverse technical skill set that includes: Asymmetric catalysis, Pd-catalyzed C-N bond formation, N-heterocyclic carbene catalysis, API process development, Pharmaceutical formulation and troubleshooting, Process scale-up and manufacturing support.
📚 Academic Contributions
Dr. White has actively published in high-impact journals, contributing to the fields of synthetic organic chemistry and process development. His research bridges fundamental catalysis with practical applications in pharmaceutical manufacturing.
👨🏫 Mentorship & Training
In addition to his research and industry roles, Dr. White has mentored junior scientists and interns, fostering talent development within Genentech and beyond, reflecting his commitment to building future leaders in chemistry.
🚀 Legacy and Future Contributions
Dr. White continues to innovate at the interface of synthetic chemistry and pharmaceutical development. His ongoing work aims to refine and optimize chemical processes that can accelerate drug development timelines while ensuring quality and sustainability in pharmaceutical production.
📖Notable Publications
Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation
Authors: C. Molinaro, N. Wong, N.A. White, S. Malhotra, F. Gosselin
Journal: Organic Process Research and Development
Year: 2024
Streamlined Synthesis of SHP2 Inhibitor GDC-1971 Enhanced by a Telescoped Schotten-Baumann SNAr and Reactive Crystallization Cascade
Authors: L.E. Sirois, N.A. White, J. Shen, F. St-Jean, F. Gosselin
Journal: Organic Process Research and Development
Year: 2024
Aryl Halide Cross-Coupling via Formate-Mediated Transfer Hydrogenation
Authors: Y. Cho, Y.-H. Chang, K.P. Quirion, Z.H. Strong, Z.J. Dubey, N. Nguyen, S. Lee, N.S. Taylor, J.M. Hoover, N.A. White, P. Liu, M.J. Krische
Journal: Nature Chemistry
Year: 2025
Manufacturing Process for 6-Bromo-N,N-bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, a Key Intermediate in the Synthesis of KRAS G12C Inhibitor Divarasib
Authors: J. Shen, N.A. White, Q. Tian, L.E. Sirois, H. Zhang, F. Gosselin
Journal: Organic Process Research and Development
Year: 2024
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036
Authors: J. Xu, N-.K. Lim, J.C. Timmerman, J. Shen, K. Clagg, U. Orcel, R. Bigler, E. Trashsel, R. Meier, N.A. White, J.A. Burkhard, L.E. Sirois, Q. Tian, R. Angelaud, S. Bachmann, H. Zhang, F. Gosselin
Journal: Organic Letters
Year: 2023