Tshwane University of Technology | South Africa
Dr. Mokgadi Precious Mphahlele is an emerging South African chemist specializing in natural product chemistry, drug discovery, and analytical techniques. She holds a PhD in Chemistry from the University of Johannesburg, where her research focused on isolating and synthesizing bioactive compounds from traditional medicinal plants (Tabernaemontana contorta, Sclerocarya birrea, and Senna italica) for use against resistant bacterial and cancerous cells. Her MSc in Chemistry involved developing a sustained delivery system for Curcuma longa extracts using advanced chromatographic and spectroscopic techniques. Dr. Mphahlele is currently a Postdoctoral Research Fellow at Tshwane University of Technology, conducting chemometric analysis and metabolomics on South African medicinal plants. She previously served as a Senior Laboratory Technician at the University of Johannesburg and a Quality Control Lab Assistant at Idwala Industrial Minerals. She has contributed to over ten peer-reviewed publications in high-impact journals, focusing on phytochemical profiling, structure elucidation, antibacterial and anticancer assays, and natural compound synthesis. Dr. Mphahlele has completed international programs such as the Lancaster University Career Writing Program, and training in Drug Discovery (UC San Diego) and Scientific Writing (Nature Masterclass). Her research interests lie in natural products chemistry, chromatographic method development, molecular networking, and structure–activity relationship (SAR) studies. She is an active member of the Golden Key Honour Society, a Black Women in Science 2024 Fellow, and a reviewer for Taylor & Francis. Dr. Mphahlele’s work bridges traditional knowledge with modern scientific innovation, contributing to sustainable health solutions.
Featured Publications
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“Isolation and Characterization of a Novel Sugar from the Inner Bark of Sclerocarya birrea: Insights into Antibiotic and Anticancer Activity”
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“Antimicrobial Activity of Triterpenoid and Steroidal Cinnamates from Vitellaria paradoxa”
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“Crystal structure of Staudtienic acid, a diterpenoid from Staudtia kamerunensis Warb.(Myristicaceae)”
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“Chemical profiling, bio-guided purification, and cytotoxic effect of two African spices: Hypodaphnis zenkeri Engl. Stapf (Lauraceae) and Staudtia kamerunensis warb (Myristicaceae) on human prostate cancer cell lines”
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“Antibacterial activity and GC-MS profiling of DCM/MeOH extracts of Tabernaemontana contorta Stapf’s leaves, and stem bark from the central region of Cameroon”