National and Kapodistrian University of Athens | Greece
Nikolaos E. Koletsis is a chemist with a Master of Science in Applied Biochemistry from the University of Patras and a Bachelor of Science in Chemistry from the University of Ioannina. His academic and research background is grounded in molecular and cellular biochemistry, with a particular emphasis on cancer biology, extracellular matrix (ECM) dynamics, and the development of three-dimensional (3D) cell culture models. During his MSc research at the Laboratory of Biochemistry, University of Patras, he investigated the functional properties and differential expression of key ECM components in 3D breast cancer spheroids. His work integrated advanced biochemical techniques including 3D cell culture, gene expression analysis (qPCR), HPLC, ELISA, electrophoresis, and statistical methodologies such as T-test and ANOVA. This project has culminated in both national and international presentations, and a first-author publication in Cells. Koletsis also conducted pioneering undergraduate research at the University of Ioannina, synthesizing novel alkaline earth metal-organic frameworks (MOFs) with potential applications in biodiesel catalysis. This work led to the identification of a new magnesium-glycerol complex, a structure reported for the first time in literature. He has co-authored three peer-reviewed journal articles indexed in Scopus, which have collectively received 15 citations, and he currently holds an h-index of 1. His publications appear in respected journals such as Cells, FEBS Journal, and Archives of Medical Science – Atherosclerotic Diseases, reflecting the interdisciplinary and impactful nature of his work. In addition to his lab-based expertise, Koletsis is adept in scientific writing, data analysis, and conference presentations, demonstrating a clear capacity for translating experimental data into meaningful scientific contributions. His career interests lie at the intersection of biomedical research, applied sciences, and translational innovations in cancer and materials chemistry.
Featured Publications
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Koletsis, N. E., Mangani, S., Franchi, M., Piperigkou, Z., & Karamanos, N. K. (2025). Development, functional characterization, and matrix effectors dynamics in 3D spheroids of triple-negative breast cancer cells. Cells, 14(17), 1351.
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Anagnostopoulos, S., Baltayiannis, N., Koletsis, N. E., et al. (2025). 3D printing in medicine: Bridging imaging, education, and practice. Archives of Medical Science – Atherosclerotic Diseases, 10(1), 172–188.
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Mangani, S., Piperigkou, Z., Koletsis, N. E., Ioannou, P., & Karamanos, N. K. (2024). Estrogen receptors and extracellular matrix: The critical interplay in cancer development and progression. FEBS Journal.
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Piperigkou, Z., Mangani, S., Koletsis, N. E., Koutsakis, C., Mastronikolis, N. S., Franchi, M., & Karamanos, N. K. (2025). Principal mechanisms of extracellular matrix-mediated cell–cell communication in physiological and tumor microenvironments. FEBS Journal.