King Saud University, Saudi Arabia
👨🎓Profiles
🎓 Early Academic Pursuits
Ahmed H. Bakheit's academic journey began with a B.Sc. (Honors) in Chemistry from Al-Neelain University in Sudan, where he was awarded the Sudan Institute for Natural Sciences Prize in 2000-2001. His thirst for knowledge continued with an M.Sc. in Analytical Chemistry, followed by a Ph.D. in Chemistry (Analytical Chemistry) in 2023, where he focused on the interaction of anticancer drugs with serum albumin and DNA. His work integrates advanced spectroscopy and molecular modeling techniques, contributing significantly to his field.
💼 Professional Endeavors
Dr. Bakheit’s professional career spans multiple roles in both teaching and research. Since June 2011, he has been a researcher at King Saud University's Department of Pharmaceutical Chemistry, Saudi Arabia. Prior to that, he served as a lecturer at Al-Neelain University in Sudan, where he also lectured at the University of Bahr al Ghazal, Sudan. These roles helped shape his expertise in analytical chemistry and pharmaceutical sciences. Dr. Bakheit also contributed through various workshops and short courses, including specialized training in spectroscopy and chromatography.
🔬 Contributions and Research Focus
Dr. Bakheit has dedicated much of his research to the development and validation of analytical techniques for pharmaceutical compounds and environmental pollutants. His primary focus areas include: Spectroscopic Investigation of Drug-Plasma Protein Interactions: Using advanced spectroscopic techniques, he studies the binding interactions between drugs and serum proteins to improve drug efficacy and pharmacokinetics. Computational Chemistry and Molecular Dynamics: His work in molecular docking and dynamic simulations aids in understanding the binding mechanisms of drugs, facilitating drug discovery and design. Pharmaceutical Quality Control & Analysis: He contributes significantly to quality control, stability studies, and impurity profiling in pharmaceutical formulations, ensuring drug safety and efficacy.
🌍 Impact and Influence
Dr. Bakheit's research has influenced drug design, bioinformatics, and pharmaceutical quality control. By integrating analytical chemistry with computational tools, his work promotes a deeper understanding of drug behavior and interactions in biological systems, influencing the fields of drug discovery, pharmacology, and pharmaceutical sciences. His contributions to bioorganic chemistry and biophysics have been vital in advancing the understanding of drug mechanisms and kinetics, paving the way for more effective and stable pharmaceutical formulations.
📚 Academic Cites & Publications
Dr. Bakheit’s academic contributions have been widely recognized in the scientific community. His work is documented on platforms like Google Scholar, where his research in analytical chemistry and drug interactions has been cited numerous times. His publications showcase his continuous pursuit of knowledge and his contributions to the advancement of pharmaceutical chemistry and related fields.
🛠️ Technical Skills
Dr. Bakheit is highly skilled in various technical areas, including: Computational Chemistry Software: Proficient in AutoDock, MOE, Gaussian 09, and Visual Molecular Dynamics (VMD). Spectroscopic & Chromatographic Techniques: Expertise in methods such as Atomic Absorption Spectroscopy, HPLC, NMR Spectroscopy, and Mass Spectrometry (LC-MS/MS). Molecular Dynamic Simulation: Skilled in using NAMD and other dynamic simulation tools to model molecular behavior.
👨🏫 Teaching Experience
Dr. Bakheit has had a long and impactful career in education. He has taught a range of subjects, including: Analytical Chemistry: Undergraduate and graduate courses at Al-Neelain University and King Saud University. Instrumental Analysis: Lecturing on techniques such as HPLC, atomic absorption, spectrophotometry, and more. Practical Chemistry: Guiding students through lab experiments to enhance their understanding of chemical analysis. His teaching approach focuses on blending theoretical knowledge with practical skills, helping students grasp complex concepts through hands-on learning.
🌱 Legacy and Future Contributions
Dr. Bakheit's legacy lies in his comprehensive approach to integrating analytical chemistry with pharmaceutical sciences, which has profound implications for drug safety and development. Moving forward, his research will likely continue to influence the development of novel drugs, better-quality control methods, and advanced therapeutic solutions. His work in drug discovery and bioinformatics is poised to contribute to the next generation of pharmaceutical innovations.
📖Notable Publications
Study of interactions of an anticancer drug neratinib with bovine serum albumin: spectroscopic and molecular docking approach
Authors: TA Wani, AH Bakheit, MA Abounassif, S Zargar
Journal: Frontiers in Chemistry
Year: 2018
Citations: 121
Multi-spectroscopic investigation, molecular docking and molecular dynamic simulation of competitive interactions between flavonoids (quercetin and rutin) and sorafenib for …
Authors: NA Alsaif, TA Wani, AH Bakheit, S Zargar
Journal: International Journal of Biological Macromolecules
Year: 2020
Citations: 105
Propranolol
Authors: AA Al-Majed, AHH Bakheit, HAA Aziz, FM Alajmi, H AlRabiah
Journal: Profiles of Drug Substances, Excipients and Related Methodology
Year: 2017
Citations: 102
Interaction of an abiraterone with calf thymus DNA: Investigation with spectroscopic technique and modelling studies
Authors: TA Wani, N Alsaif, AH Bakheit, S Zargar, AA Al-Mehizia, AA Khan
Journal: Bioorganic Chemistry
Year: 2020
Citations: 89
Fluorescence spectroscopic and molecular docking studies of the binding interaction between the new anaplastic lymphoma kinase inhibitor crizotinib and bovine serum albumin
Authors: AS Abdelhameed, AM Alanazi, AH Bakheit, HW Darwish, HA Ghabbour, ...
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Year: 2017
Citations: 82
Spectrophotometric and molecular modelling studies on in vitro interaction of tyrosine kinase inhibitor linifanib with bovine serum albumin
Authors: TA Wani, AH Bakheit, S Zargar, MA Hamidaddin, IA Darwish
Journal: PLoS One
Year: 2017
Citations: 80