Xiaofei Cheng | Molecular Biology | Best Research Article Award

Published on by Analytical Chemistry

Prof. Dr. Xiaofei Cheng | Molecular Biology | Best Research Article Award

Vice Dean | Northeast Agricultural University | China

Professor Xiaofei Cheng is a distinguished molecular plant pathologist and biochemist at the College of Agriculture, Northeast Agricultural University, Harbin, China. His research focuses primarily on the molecular mechanisms underlying plant-virus interactions, with a particular emphasis on host immune modulation, viral pathogenicity, and RNA virus replication and movement. Through extensive collaborative research with national and international institutes, including Agriculture and Agri-Food Canada and the National Centre for Biotechnology (CSIC, Spain), Professor Cheng has made pioneering contributions to understanding how plant viruses exploit host cellular machinery to establish successful infections. A central theme of Cheng’s research involves elucidating how RNA viruses manipulate plant immunity. His team discovered that plant viruses can hijack host phosphatases to attenuate MAPK-mediated immunity, enabling robust infection. Moreover, his studies revealed the existence of pathogen protease-activated molecular decoys, offering potential for engineering customized resistance in plants. Cheng also uncovered viral strategies to target NPR1, a master regulator of salicylic acid (SA)-mediated defense, thereby suppressing antiviral immunity. His research extends to virus-encoded small proteins, viral replication vesicle formation, and intercellular virus movement. Earlier, Cheng’s work demonstrated that sumoylation of viral RNA polymerase promotes infection by subverting NPR1-mediated immunity, and that viral suppressor proteins such as VPg can degrade key host silencing factors via autophagy pathways. With over 96 publications, 1,635 citations, and an h-index of 23 (Scopus), Professor Cheng has established himself as a leading figure in molecular plant virology and biotechnology. His findings not only deepen our understanding of host-pathogen molecular interplay but also pave the way for developing virus-resistant crop varieties, contributing significantly to global agricultural sustainability.

Profiles : Scopus | ORCID | Google Scholar | Research Gate

Featured Publications

  • Luan, Y., Jiang, X., Wang, Y., Chai, M., Li, F., Wang, A., Wu, X., & Cheng, X. (2025). A plant RNA virus hijacks a membrane-anchored dual-specificity phosphatase to attenuate MAPK-mediated immunity for robust infection. The Plant Cell.

  • Fan, X., Zhao, Y., Ji, W., Rodamilans, B., Simón-Mateo, C., García, J. A., Wu, X., & Cheng, X.* (2025). A pathogen protease-activated molecular decoy for customized resistance in plant. Plant Biotechnology Journal, 23, 2403–2405.

  • Jiang, X., Yang, Y., Li, Y., Wang, Y., Rodamilans, B., Ji, W., Wu, X., García, J. A., Wu, X., & Cheng, X. (2025). Plant viruses convergently target NPR1 with various strategies to suppress salicylic acid-mediated antiviral immunity. Journal of Integrative Plant Biology, 67(5), 1395–1412.

  • Chai, M., Li, L., Li, Y., Yang, Y., Wang, Y., Jiang, X., Luan, Y., Li, F., Cui, H., Wang, A., Xiang, W., Wu, X., & Cheng, X.* (2024). The 6-kilodalton peptide 1 in plant viruses of the family Potyviridae is a viroporin. Proceedings of the National Academy of Sciences of the United States of America, 121(21), e2401748121.

  • Liu, J., Wu, X., Fang, Y., Liu, Y., Bello, E. O., Li, Y., Xiong, R., Li, Y., Fu, Z. Q., Wang, A., & Cheng, X.* (2023). A plant RNA virus inhibits NPR1 sumoylation and subverts NPR1-mediated plant immunity. Nature Communications, 14, 3580.

Fei Zhu | Chemical Biology | Best Researcher Award

Published on by Analytical Chemistry

Assoc. Prof. Dr. Fei Zhu | Chemical Biology | Best Researcher Award

Xi’an Jiaotong-Liverpool University, China

👨‍🎓Profiles

🎓 Early Academic Pursuits

Assoc. Prof. Dr. Fei Zhu’s academic journey began with a strong foundation in pharmaceutical sciences and biomedical research. His early studies focused on stem cell biology, regenerative medicine, and biomaterials, laying the groundwork for his future contributions to pluripotent stem cell research and tumor immunotherapy. With a deep passion for scientific discovery, he explored innovative methodologies for cell reprogramming and tissue engineering, positioning himself as a leading expert in the field.

🏛 Professional Endeavors

Dr. Zhu is currently an Associate Professor at the Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, China. His professional career is dedicated to advancing cell-based therapies and personalized medicine. He has played a pivotal role in the development of functional biomaterials that enhance cell reprogramming and organoid-based drug evaluation. His expertise extends to designing novel cancer vaccines derived from stem cell membranes, aimed at multi-cancer prevention. Through his academic and research leadership, he has fostered interdisciplinary collaborations, bridging the gap between biomedical engineering and clinical applications.

🔬 Contributions and Research Focus

Dr. Zhu’s research revolves around four key areas. His work in cell reprogramming has led to the development of highly efficient techniques using transcription factor cocktails and biomaterial-based approaches. In pluripotent stem cell-based therapy, his advancements in islet organoid development offer new possibilities for diabetes treatment. His contributions to tumor organoid-based drug evaluation have enabled the construction of patient-derived tumor organoids, allowing for precise assessments of drug efficacy, resistance, and safety.

🌍 Impact and Influence

Dr. Zhu’s research is making a significant impact in regenerative medicine and cancer therapy. His innovations in stem cell technology and biomaterials have profound implications for disease modeling, drug screening, and personalized treatment strategies. His groundbreaking publications in high-impact journals such as Nature Biomedical Engineering, Advanced Materials, and Stem Cell Reports have positioned him as a thought leader in the scientific community, influencing both academic research and potential clinical applications.

📖 Academic Citations and Recognition

Dr. Zhu’s impactful research has earned widespread recognition in leading scientific journals and international forums. His work has been cited extensively in studies related to stem cell therapy, biomaterials, and cancer immunotherapy. His insights into cell reprogramming and tumor organoids continue to shape modern biomedical sciences, contributing to the advancement of precision medicine.

🛠 Technical Skills and Expertise

Dr. Zhu possesses a diverse skill set in biomedical research, including expertise in stem cell differentiation and reprogramming, advanced biomaterial design for therapeutic applications, organoid development and drug screening, nanotechnology-based cancer immunotherapy, and high-throughput screening techniques for drug discovery. His technical expertise enables him to drive innovation in cell-based therapies and regenerative medicine.

👨‍🏫 Teaching and Mentorship

As a dedicated educator, Dr. Zhu is committed to mentoring the next generation of researchers. He actively trains students and young scientists in stem cell engineering, regenerative medicine, and tumor immunotherapy. His guidance helps students develop innovative thinking, research skills, and translational expertise, preparing them for careers in academia and industry.

🚀 Legacy and Future Contributions

Dr. Zhu’s work is paving the way for transformative advancements in medicine. His future research aims to enhance tumor organoid technology for better drug screening, develop next-generation cancer immunotherapies, improve biomaterial-based approaches for cell therapy, and translate laboratory discoveries into clinical applications for personalized medicine. With his dedication to scientific innovation, Dr. Zhu continues to push the boundaries of biomedical research, shaping the future of cell-based therapies and cancer treatment. His work holds immense promise for improving patient care and advancing global healthcare solutions.

📖Notable Publications

  • Cell-Reprogramming-Inspired Dynamically Responsive Hydrogel Boosts the Induction of Pluripotency via Phase-Separated Biomolecular Condensates

    • Authors: Fei Zhu, Nan Yan, X. Lu, J. Xu, H. Gu, J. Liang, K. Cheng, X. Wang, X. Ma, N. Ma, et al.

    • Journal: Advanced Materials

    • Year: 2024

  • Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells

    • Authors: Nan Li, Hao Qin, Fei Zhu, Hao Ding, Yang Chen, Yixuan Lin, Ronghui Deng, Tianyu Ma, Yuanyuan Lv, Changhao Xiong, et al.

    • Journal: Nature Biomedical Engineering

    • Year: 2024

  • Nanoparticle-based combination therapy enhances fulvestrant efficacy and overcomes tumor resistance in ER-positive breast cancer (Preprint)

    • Authors: Bozhao Li, Feilong Qi, Fei Zhu, Zefang Lu, Meiqi Wang, Tianjiao Chu, Suying Wu, Jingyan Wei, Zhenchuan Song, Saraswati Sukumar, et al.

    • Journal: Preprint

    • Year: 2024

  • Supplementary Data from Nanoparticle-based combination therapy enhances fulvestrant efficacy and overcomes tumor resistance in ER-positive breast cancer (Preprint)

    • Authors: Bozhao Li, Feilong Qi, Fei Zhu, Zefang Lu, Meiqi Wang, Tianjiao Chu, Suying Wu, Jingyan Wei, Zhenchuan Song, Saraswati Sukumar, et al.

    • Journal: Preprint

    • Year: 2024