Liu Yakun | Biochemistry | Best Innovation Award

Dr. Liu Yakun | Biochemistry | Best Innovation Award

The Fourth Hospital of Hebei Med, China

👨‍🎓Profiles

🎓 Early Academic Pursuits

Dr. Liu YaKun earned a Doctor of Medicine degree from the prestigious Hebei Medical University. From the beginning of her academic journey, she displayed a deep commitment to women’s health and a strong passion for advancing clinical knowledge in gynecology. Her formative years were shaped by rigorous medical education, clinical rotations, and early exposure to research in gynecologic oncology.

💼 Professional Endeavors

Currently serving as the Associate Chief Physician at the Department of Gynecology, Fourth Hospital of Hebei Medical University, Dr. Liu also holds the significant position of Teaching Director. In this dual role, she combines her medical expertise with academic leadership, mentoring young doctors and medical students. Her clinical work is particularly focused on the diagnosis and surgical treatment of gynecologic tumors, and she is widely recognized for her meticulous approach and dedication to patient care.

🔬 Contributions and Research Focus

Dr. Liu’s primary research area lies in gynecologic tumors, especially ovarian malignancies. In a groundbreaking study, she and her team became the first in the world to identify a rare germline BMP15 mutation as a causative factor in hereditary ovarian immature teratoma (OIT). Through a combination of cell line experiments and animal models, the pathogenicity of this mutation was verified, significantly advancing the understanding of the etiology of OIT. This work not only provided a crucial biomarker for genetic screening but also paved the way for future studies on ovarian malignant germ cell tumors.

🌍 Impact and Influence

Dr. Liu’s discovery has had a global impact, offering new insights into rare gynecologic cancers and influencing genetic screening protocols worldwide. Her pioneering research has opened new avenues in oncology, particularly in the identification and treatment of hereditary tumors in women, thus contributing significantly to precision medicine in gynecology.

📚 Academic Citations and Recognition

As a first author, Dr. Liu has published numerous papers in SCI-indexed and core medical journals, contributing high-impact literature to the field. She has led multiple research projects and was honored with the First Prize of the Hebei Medical Science and Technology Award, underscoring her scientific excellence and clinical relevance.

🧪 Technical Skills

Dr. Liu is proficient in a wide range of clinical and laboratory techniques, including tumor marker analysis, surgical oncology procedures, molecular biology experiments, and animal model development. Her work seamlessly integrates clinical practice with laboratory research, enabling her to translate bench-side findings into bedside applications.

👩‍🏫 Teaching Experience

As the Teaching Director of her department, Dr. Liu is deeply involved in medical education and mentoring. She designs and delivers advanced training modules for residents and interns, oversees their clinical rotations, and encourages them to participate in research. Her teaching style is both inspiring and practical, often merging clinical scenarios with research discussions to foster comprehensive learning.

🌟 Legacy and Future Contributions

Dr. Liu YaKun’s legacy is being built on a foundation of clinical innovation, academic excellence, and compassionate care. She aims to further explore genetic mutations in gynecologic oncology, contribute to personalized medicine, and mentor the next generation of gynecologists. Her future work will likely continue to bridge the gap between clinical practice and genetic research, reinforcing her standing as a trailblazer in women’s health.

📖Notable Publications

New insights into the ferroptosis and immune infiltration in endometriosis: a bioinformatics-based analysis

Authors: Lusha Liu, Feifei Han, Naiyi Du, Yakun Liu, Aihong Duan, Shan Kang, Bin Li
Journal: Frontiers in Immunology
Year: 2025

Incorporating genotype information in a precise prediction model for platinum sensitivity in epithelial ovarian cancer

Authors: Nai-Yi Du, Yan Li, Hui Zheng, Ya-Kun Liu, Lu-Sha Liu, Jianbang Xie, Shan Kang
Journal: Frontiers in Oncology
Year: 2025

Stratifin (SFN) Regulates Cervical Cancer Cell Proliferation, Apoptosis, and Cytoskeletal Remodeling and Metastasis Progression Through LIMK2/Cofilin Signaling

Authors: Naiyi Du, Daojuan Li, Wei Zhao, Yakun Liu
Journal: Molecular Biotechnology
Year: 2024

The Diagnostic Significance of Combined Screening and Human Papillomavirus 16 and 18 Cycle Threshold Values for CIN2+ Cervical Lesions

Authors: Xue Bai, Ya-Kun Liu, Ya-Jing Jia, Dao-Juan Li, Nai-Yi Du
Journal: International Journal of Women’s Health
Year: 2024

Causal effects of genetically determined circulating metabolites on endometriosis: A Mendelian randomization study

Authors: Lusha Liu, Junping Yin, Yakun Liu, Bin Li, Shan Kang, Naiyi Du
Journal: Medicine
Year: 2024

LIMK1 promotes the development of cervical cancer by up-regulating the ROS/Src-FAK/cofilin signaling pathway

Authors: Yajing Jia, Yongping Li, Naiyi Du, Wei Zhao, Yakun Liu
Journal: Aging
Year: 2024

Yaoyao Li | Bioinformatics | Best Researcher Award

Assoc. Prof. Dr. Yaoyao Li | Bioinformatics | Best Researcher Award

Xidian University, China

👨‍🎓Profiles

Early Academic Pursuits 🎓

Yaoyao Li, Ph.D., began her academic journey at Xidian University, where she earned her Ph.D. in Computer Science and Technology in June 2020. During her doctoral studies, she focused on computational techniques for analyzing biomolecular data, particularly DNA genome sequences. Her early academic pursuits were marked by a strong foundation in machine learning algorithms, probability theory, and statistical methods applied to bioinformatics. Her work aimed to detect and identify variant sites or fragments within DNA, uncovering patterns with potential biological functions. This laid the groundwork for her future contributions to computational bioinformatics and genomic research.

Professional Endeavors 💼

Following the completion of her Ph.D., Dr. Li worked at Alibaba Group from July 2020 to June 2022. Here, she was responsible for researching user growth algorithms for business-to-business (B2B) applications. Her work contributed to key innovations in user engagement, earning her the Core Innovation Technology Award. This professional experience allowed her to bridge the gap between theoretical research and real-world applications. After her tenure at Alibaba, she continued her academic journey by completing postdoctoral research at Xidian University in June 2024, solidifying her expertise in computational techniques and bioinformatics.

Contributions and Research Focus 🔬

Dr. Li's research is at the intersection of machine learning, computer vision, computational bioinformatics, and cancer genome data mining. Her primary focus is on analyzing biomolecular data to reveal biological insights hidden within DNA sequences. She employs comprehensive machine learning algorithms and probabilistic methods to detect variant sites or identify DNA fragments, helping to uncover biological patterns that may play a role in diseases such as cancer. Dr. Li is particularly passionate about integrating statistical tests with advanced machine learning models to improve accuracy in genome sequence prediction.

Impact and Influence 🌍

Dr. Li's work has had a significant impact on the field of bioinformatics and genomic research. By developing algorithms that can detect variant sites in the DNA genome, her contributions are pivotal in understanding complex genetic diseases, especially cancer. Her research also aids in the development of precision medicine, where targeted therapies can be crafted based on an individual’s genetic makeup. The practical implications of her research extend to biotechnology companies, healthcare providers, and academic institutions focused on genomics.

In addition to her research, Dr. Li's efforts to contribute to the academic community are reflected in her involvement with prestigious journals such as "Digital Signal Processing", "IEEE/ACM Transactions on Computational Biology and Bioinformatics", and "Biomedical Optics Express". Her papers have been widely cited, making her a respected voice in the fields of computational biology and bioinformatics.

Academic Cites and Recognition 📚

Dr. Li’s research has been widely recognized within the academic community. Her contributions to bioinformatics and computational techniques have been cited in major international journals, reinforcing her reputation as a leader in the field. Her publications in well-respected journals, such as IEEE/ACM Transactions on Computational Biology and Biomedical Optics Express, have garnered attention for their innovative approaches to cancer genome data mining and DNA sequence analysis. These citations are a testament to her academic influence and the relevance of her work to both fundamental and applied science.

Technical Skills 🛠️

Dr. Li’s expertise spans several domains of computational science, particularly in the application of machine learning algorithms, probability theory, and statistical methods. She is highly skilled in using these techniques to detect variant sites, identify fragments in DNA genomes, and mine cancer genomic data. Her proficiency with computer vision methods further strengthens her research capabilities, allowing her to work with complex biological data sets. Dr. Li is also adept at leveraging sequence prediction models to enhance the accuracy of her findings.

Teaching Experience 👩‍🏫

Dr. Li has shared her knowledge and expertise through her involvement in teaching and mentoring students. While her focus has been on cutting-edge research, she has also contributed to the academic growth of her students, guiding them through complex topics in bioinformatics, machine learning, and computational biology. Her ability to simplify intricate scientific concepts has made her a respected mentor, and she continues to inspire the next generation of researchers in her field.

Legacy and Future Contributions 🔮

Dr. Li's legacy is one of blending advanced computational techniques with real-world biomedical applications. Her work has already made a substantial impact in the field of genomic research, particularly in cancer genomics, and has the potential to revolutionize how diseases are diagnosed and treated. Looking to the future, she aims to further expand the applications of machine learning in genomic research and bioinformatics, exploring new methods for early detection of genetic diseases. She is also committed to advancing the precision medicine field, ensuring that personalized healthcare strategies are built on robust genomic data analysis.

Final Thoughts 🌟

Dr. Yaoyao Li is a trailblazer in computational bioinformatics, and her research has already had a profound impact on the scientific community. With her expertise in machine learning, bioinformatics, and cancer genomics, she is poised to continue making significant contributions that will not only advance academic knowledge but also improve health outcomes through precision medicine. Her journey is a testament to the power of combining computational technology with biological science to solve some of the most pressing challenges in modern healthcare.

📖Notable Publications

CNV_MCD: Detection of copy number variations based on minimum covariance determinant using next-generation sequencing data

Authors: Li, Y., Yang, F., Xie, K.
Journal: Digital Signal Processing: A Review Journal
Year: 2024

Intelligent scoring system based on dynamic optical breast imaging for early detection of breast cancer

Authors: Li, Y., Zhang, Y., Yu, Q., He, C., Yuan, X.
Journal: Biomedical Optics Express
Year: 2024

CONDEL: Detecting Copy Number Variation and Genotyping Deletion Zygosity from Single Tumor Samples Using Sequence Data

Authors: Yuan, X., Bai, J., Zhang, J., Li, Y., Gao, M.
Journal: IEEE/ACM Transactions on Computational Biology and Bioinformatics
Year: 2020

DpGMM: A Dirichlet Process Gaussian Mixture Model for Copy Number Variation Detection in Low-Coverage Whole-Genome Sequencing Data

Authors: Li, Y., Zhang, J., Yuan, X., Li, J.
Journal: IEEE Access
Year: 2020

BagGMM: Calling copy number variation by bagging multiple Gaussian mixture models from tumor and matched normal next-generation sequencing data

Authors: Li, Y., Zhang, J., Yuan, X.
Journal: Digital Signal Processing: A Review Journal
Year: 2019

SM-RCNV: A statistical method to detect recurrent copy number variations in sequenced samples

Authors: Li, Y., Yuan, X., Zhang, J., Bai, J., Jiang, S.
Journal: Genes and Genomics
Year: 2019

Sicong Ma | Theoretical and Computational Chemistry | Best Researcher Award

Assoc. Prof. Dr. Sicong Ma | Theoretical and Computational Chemistry | Best Researcher Award

Shanghai Institute of Organic Chemistry, China

👨‍🎓Profiles

🎓 Early Academic Pursuits

Dr. Sicong Ma, born in March 1992, began his academic journey with a strong foundation in applied chemistry at the China University of Petroleum (Beijing), where he completed his Bachelor of Science in 2013. He continued at the same institution for a Master's degree in Chemistry, working under the guidance of Professor Zhen Zhao until 2016. His academic path led him to Fudan University, where he earned his Ph.D. in Physical Chemistry in 2019 under Professor Zhi-Pan Liu. Here, he developed his expertise in theoretical and computational chemistry, laying the groundwork for his future contributions to catalysis and machine learning.

🏢 Professional Endeavors

After completing his Ph.D., He joined Fudan University as a postdoctoral researcher, continuing his work with Professor Zhi-Pan Liu until 2021. In August 2021, he joined the Shanghai Institute of Organic Chemistry as an Assistant Researcher. Recently promoted to Associate Professor, He has led several projects funded by prestigious institutions, including the National Natural Science Excellent Youth Fund, Shanghai Municipal Science and Technology Commission, and the China Postdoctoral Fund.

🔍 Contributions and Research Focus

His research interests span a unique blend of machine learning and catalysis. His expertise extends across both homogeneous and heterogeneous catalysis, with a particular focus on: Machine Learning and Heterogeneous Catalysis: He has conducted research on syngas-to-olefins conversions on OX-ZEO catalysts, propane hydrogenation, and similar transformations, Machine Learning and Homogeneous Catalysis: His work includes studies on the carbonylation of olefins and the development of a metal-phosphine ligand catalyst database, Zeolite Chemistry: He is also active in studying the mechanisms of zeolite formation and their applications in catalysis, contributing significantly to zeolite-related database construction.

📈 Impact and Influence

He has made substantial contributions to the field, publishing more than 20 papers in renowned journals such as Nature Catalysis, Nature Communications, and ACS Catalysis. Notably, he has served as first or corresponding author on 15 of these publications, solidifying his role as a leader in his field. His work has garnered attention and citations, reflecting his influence within theoretical and computational chemistry.

📚 Academic Achievements and Honors

Recognized for his academic excellence, He has received numerous awards and honors. He was honored with the Excellent Doctoral Dissertation Award from Fudan University in 2019, recognized as an Academic Star of Fudan University the same year, and awarded a Shanghai Super Postdoctoral Fellowship. Recently, he was inducted as a member of the Youth Innovation Promotion Association by the Chinese Academy of Sciences in 2023.

🛠️ Technical Skills

His technical expertise includes advanced machine learning algorithms for catalysis, computational modeling in chemistry, and extensive knowledge of catalysis mechanisms in both homogeneous and heterogeneous systems. His computational skills and programming knowledge enable him to create and manage large databases, crucial for his projects on zeolite and catalyst-related data.

📖 Teaching and Mentoring Experience

While focused primarily on research, He has also contributed to the academic community by mentoring postdocs and junior researchers in his lab. His guidance fosters a collaborative environment, ensuring that emerging researchers develop the skills necessary to advance in computational chemistry and catalysis.

🌐 Legacy and Future Contributions

His ongoing work promises to deepen the integration of machine learning in catalysis, with potential implications for sustainable energy solutions and efficient industrial chemical processes. As a young innovator and leader in his field, he is set to make lasting contributions, furthering both academic knowledge and practical applications in computational chemistry.

📖Notable Publications